The therapeutic effects of hydrogen on central nervous system disease May 27,2022.

The therapeutic effects of hydrogen on central nervous system disease

Since the discovery of biological effects of hydrogen, hydrogen has been shown to protect against central nervous system disorders, including Alzheimer's disease and cerebrovascular disease.


1. The therapeutic effect of hydrogen on cerebrovascular disease


Ohsawa et al reported in 2007 after breathing hydrogen on the left middle cerebral artery occlusion model in rats. Sun Xuejun and others soon proved that breathing hydrogen gas had an ideal therapeutic effect on hypoxic-ischemic brain damage caused by neonatal asphyxia, and found that hydrogen gas had an inhibitory effect on neuronal apoptotic enzyme activity after hypoxic-ischemic brain damage, the decrease of apoptotic enzyme activity resulted in the decrease of neuronal apoptosis and the decrease of neuronal necrosis. This reduces brain damage and protects brain function in adulthood. Hydrogen has a protective effect on brain injury caused by cardiac arrest, which further confirms the protective effect of hydrogen on hypoxic-ischemic brain injury. Edaravone is currently the only anti-oxidant approved for use in stroke treatment, and hydrogen in combination with edaravone improves these nmeasures better than Edaravone alone. The Loma Linda Institute of Neurosurgery in the United States and the neurosurgery departments of the Nanjing Medical University and the Affiliated Hospital of Zhejiang University have reported that hydrogen breath and injection of hydrogen physiological saline have ideal protective effects on early brain injury, neuronal necrosis, cerebral edema and vasospasm induced by intracerebral hemorrhage and subretinal hemorrhage.


2. Hydrogen for Neurodegeneration


Parkinson's disease is caused by the death of dopaminergic neurons in the substantia nigra of the brainstem nucleus and is often a secondary manifestation of many other diseases, such as Neurodegeneration dementia. Sun and others began giving the animals hydrogen saturated water a week before the model was created, and found that the treatment completely eliminated the symptoms of unilateral BA Jin's disease. The number of dopaminergic neurons in the non-treatment group decreased to 40.2% compared with the control group, but only to 83% in the treatment group. Even after treatment with hydrogen water 3 days after the model was established, symptoms of unilateral BA Jin's disease were suppressed, but the effect of treatment was lower than that of prior treatment, and the number of neurons was reduced to 76.3% compared with the control. After 48 hours of model preparation, the activity of dopamine neurons in the striatum representing the Tyrosine 3-monooxygenase in the model control group and the treatment group decreased significantly. Fujita et al. demonstrated a similar effect with MPTP-induced mouse model of Parkinson's disease. The results show that hydrogen has a better therapeutic effect than other drugs such as ginkgo biloba.



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