Clinical study on hydrogen treatment of senile dementia
Sep 3,2021
Oxidative stress is one of the pathogenesis of many major neurodegenerative diseases, including Alzheimer's disease, mild cognitive impairment and Parkinson's disease.
The ALDH2 gene is a gene encoding mitochondrial acetaldehyde dehydrogenase, which has dehydrogenase activity, plays an effect on the oxidation of acetaldehyde in the human body, and is related to the ability of alcohol metabolism. The catabolism of alcohol in the body mainly relies on two enzymes, alcohol dehydrogenase ADH and acetaldehyde dehydrogenase ALDH. When alcohol enters the body, it will be decomposed into acetaldehyde under the action of ADH, and then decomposed into acetic acid under the action of ALDH, and then discharged. in vitro. Among ALDH2-deficient mice, mice that were given alcohol (5.8g per kilogram of body weight) had 4 times more cells undergoing DNA damage than mice that were not given alcohol. People with this mutation cannot synthesize enough acetaldehyde dehydrogenase to degrade acetaldehyde, and acetaldehyde cannot be eliminated from the body in time. If too much acetaldehyde accumulates in the body, it will make the face easy to drink. Such people who drink and blush suffer from esophagus. The risk of cancer is greatly increased, and such people are also more likely to develop senile dementia. Mice with this gene defect are very susceptible to Alzheimer's disease.
A large number of studies have found that hydrogen has the effect of reducing oxidative damage. The medical effect of hydrogen has been proven by a large number of animal experiments and 25 clinical studies, including some double-blind placebo-controlled clinical trials. Methods of using hydrogen include inhaling hydrogen, drinking hydrogen water, and injecting hydrogen saline. These methods have been proven to produce anti-oxidant and anti-inflammatory effects.
Drinking hydrogen water can prevent the loss of learning and memory ability caused by chronic restraint stress by reducing oxidative stress, and protect nerve cells by stimulating the release of ghrelin in the gastrointestinal tract. Hydrogen-rich normal saline injection can reduce oxidative stress and play a therapeutic role in amyloid-induced dementia. Inhalation of hydrogen gas has a therapeutic effect on brain damage after cardiac arrest and resuscitation. This effect is different from the way of hypothermia protection.
According to the results of the Alzheimer's disease score, drinking hydrogen water for one year cannot delay the development of ordinary people with moderate cognitive impairment, but it can significantly improve the cognitive impairment of APOE4 carriers.
